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Bioinorganic Chemistry

General data

Course ID: 0600-S1-CM-CBioN
Erasmus code / ISCED: 13.3 The subject classification code consists of three to five digits, where the first three represent the classification of the discipline according to the Discipline code list applicable to the Socrates/Erasmus program, the fourth (usually 0) - possible further specification of discipline information, the fifth - the degree of subject determined based on the year of study for which the subject is intended. / (0531) Chemistry The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title: Bioinorganic Chemistry
Name in Polish: Chemia bionieorganiczna
Organizational unit: Faculty of Chemistry
Course groups: (in Polish) Studia stacjonarne I stopnia - kierunek: Chemia Medyczna - semestr 3
ECTS credit allocation (and other scores): 0 OR 1.00 (depends on study program) Basic information on ECTS credits allocation principles:
  • the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS;
  • the student’s weekly hourly workload is 45 h;
  • 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes;
  • weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS;
  • work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load.
view allocation of credits
Language: Polish
Prerequisites:

Basic knowledge of biochemistry and coordination chemistry.
Total student workload:

lecture, (15h), laboratory (15h), i.e. 30 contact hours,

the total time of the student's workload is 30h = 1 ECTS
Learning outcomes - knowledge:

Student:

K_W01: knows bioinorganic chemistry and uses the appropriate terminology and nomenclature X1A_W01

K_W08: defines the concepts and explains the mechanisms of oxidative and carcinogenic processes in the human body P1A_W01; P1A_W03; P1A_W04; P1A_W05; P1A_W08

K_W11: knows to understand the basic problems related to, among others, the transport of oxygen X1A_W02; X1A_W03 X1A_W04; X1A_W05 P1A_W10; P1A_W11
Learning outcomes - skills:

Student

K_U01: can analyze and solve problems of bioinorganic chemistry based on the acquired knowledge X1A_U01; X1A_U06

X1A_U07 P1A_U01; P1A_U06 P1A_U07; P1A_U09

K_U07: can determine the structure and function of proteins, DNA, metalloenzymes, X1A_U01; X1A_U06; X1A_U07

K_U08: can describe and present chemical and biological issues using specialist language X1A_U05; X1A_U0; X1A_U08 P1A_U08; P1A_U09 P1A_U10

K_U09: can independently expand knowledge in the field of bioinorganic chemistry using scientific literature X1A_U07: P1A_U02 P1A_U03; P1A_U05 P1A_U10.
Learning outcomes - social competencies:

Student

K_K01: understands the need for continuous improvement and improvement of competencies in the field of bioinorganic chemistry X1A_K01; X1A_K05 P1A_K01; P1A_K05 P1A_K07

K_K03: can plan and deliver a presentation based on the available scientific literature X1A_K03.P1A_K04

K_K04: identifies and solves problems related to bioinorganic chemistry X1A_K04, P1A_K03; P1A_K04 P1A_K05

K_K06: understands the ethical and social aspects of using acquired knowledge and skills X1A_K07 P1A_K01; P1A_K07.
Teaching methods:

(in Polish) Wykład

Metody dydaktyczne eksponujące - pokaz

Metody dydaktyczne podające - wykład informacyjny (konwencjonalny), wykład konwersatoryjny

laboratoryjna

Metody dydaktyczne poszukujące - ćwiczeniowa, seminaryjna.
Observation/demonstration teaching methods:

- display
Expository teaching methods:

- informative (conventional) lecture
- problem-based lecture
Exploratory teaching methods:

- laboratory
Short description: (in Polish)

Celem przedmiotu jest zapoznanie studentów z wybranymi zagadnieniami chemii bionieorganicznej dotyczącymi m.in. działania ważnych dla życia biopierwiastków, funkcją w żywym organizmie związków organicznych oddziałujących jako bioligandy z jonami metali oraz rolą metali we współczesnej medycynie.
Full description:

This interdisciplinary lecture discusses: - the action of elements important for life, - the function in a living organism of organic molecules (so-called life molecules) interacting as bioligands with metal ions (biometals), especially from the point of view of coordination chemistry, - the use of coordination compounds in medicine. T

Topics covered:

1. Bioelements and toxic metals.

2. Metals in biological processes.

3. Relations between the chemical properties of a metal ion and its biological function.

4. The role of organic molecules (so-called life molecules) in a living organism interacting as bioligands with metal ions (biometals).

5. Metalloenzymes and metal ion-activated enzymes.

6. Oxygen transporters and oxygen-transporting proteins.

7. Properties of reactive oxygen species and their biological effects.

8. Metals in medicine; Inorganic chemotherapeutics as an introduction to drug chemistry.

Laboratory

During laboratory classes, students perform three exercises:

1. Application of IR spectroscopy for determining cytotoxic structures

complexes of metals in the solid state.

2. Lipophilicity test of coordination compounds selected

using UV-VIS spectroscopy.

3. Study of the reactivity of coordination compounds to glutathione.
Bibliography:

1. R. Hay, Chemia bionieorganiczna, PWN 1990.

2. S. Lippard, J.M. Berg, Podstawy chemii bionieorganicznej, PWN 1998.

3. I. Bertini, H. B. Gray, S. J. Lippard, J.S. Valentine, Bioinorganic chemistry, University Science Books

4. G. Bartosz, Druga twarz tlenu, PWN 2003.

5. H. Koroniak, J. Barciszewski, Na pograniczu chemii i biologii, Wydawnictwo Naukowe UAM, Poznań 2000.

6. L. Stryer, Biochemia, PWN 2007.

7. J.M. Perez, M.A. Fuertes, C. Alonso, Metal Compound in Cancer Chemotherapy, Research Singpost, India 2005.

8. B. Lippert, Cisplatin. Chemistry and Biochemistry of a Leading Anticancer Drug, Wiley-VCH, Weinheim 1999.

9. G. M. Blackburn, M. J.Gait, D. Loakes, D.M. Williams, Nucleic Acids in Chemistry and Biology, RSC2006.

10. H-B. Kraatz, N. Metzler-Nolte, Concepts and models in Bioinorganic Chemistry, Wiley 2006.
Assessment methods and assessment criteria:

Lecture

written exam – K_W01, K_W03; K_W08; K_W11; K_U01; K_U03; K_U07; K_U08; K_U09; K_K01; K_K03; K_K06.

Laboratory - preparation of reports on laboratory tasks performed – K_W01, K_W03; K_W08; K_W11; K_U01; K_U03; K_U07; K_U08; K_U09; K_K01; K_K03; K_K06
Internships:

Not applicable

Classes in period "Winter semester 2022/23" (past)

Time span: 2022-10-01 - 2023-02-19
Selected timetable range:
Go to timetable
Type of class:
Lecture, 15 hours more information
Tutorial, 15 hours more information
Coordinators: Iwona Łakomska
Group instructors: Anna Katafias, Iwona Łakomska
Students list: (inaccessible to you)
Credit: Grading

Classes in period "Summer semester 2023/24" (past)

Time span: 2024-02-20 - 2024-09-30
Selected timetable range:
Go to timetable
Type of class:
Laboratory, 15 hours more information
Lecture, 15 hours more information
Coordinators: Iwona Łakomska
Group instructors: Adriana Kaszuba, Iwona Łakomska
Students list: (inaccessible to you)
Credit: Course - Examination
Laboratory - Grading
Lecture - Examination
Short description: (in Polish)

Ten interdyscyplinarny wykład przybliża:

- działanie ważnych dla życia biopierwiastków,

- funkcję w żywym organizmie cząsteczek organicznych (tzw. cząsteczek życia) oddziałujących jako bioligandy z jonami metali (biometali), zwłaszcza z punktu widzenia chemii koordynacyjnej,

- zastosowanie związków koordynacyjnych w medycynie.

W trakcie wykładu poruszone zostaną następujące tematy:

1. Biopierwiastki i metale toksyczne.

2. Metale w procesach biologicznych.

3. Relacje między właściwościami chemicznymi jonu metalu a jego funkcją biologiczną.

4. Rola cząsteczek organicznych (tzw. cząsteczek życia) w organizmie żywym oddziałujących jako bioligandy z jonami metali (biometali).

5. Metaloenzymy i enzymy aktywowane jonami metali.

6. Przenośniki tlenu i białka transportujące tlen.

7. Właściwości reaktywnych form tlenu i ich biologiczne skutki.

8. Metale w medycynie; nieorganiczne chemioterapeutyki jako wprowadzenie do chemii leków.
Full description: (in Polish)

Zakres poruszanych tematów:

1. Biopierwiastki i metale toksyczne.

2. Metale w procesach biologicznych.

3. Relacje między właściwościami chemicznymi jonu metalu a jego funkcją biologiczną.

4. Rola cząsteczek organicznych (tzw. cząsteczek życia) w organizmie żywym oddziałujących jako bioligandy z jonami metali (biometali).

5. Metaloenzymy i enzymy aktywowane jonami metali.

6. Przenośniki tlenu i białka transportujące tlen.

7. Właściwości reaktywnych form tlenu i ich biologiczne skutki.

8. Metale w medycynie; nieorganiczne chemioterapeutyki jako wprowadzenie do chemii leków.
Bibliography: (in Polish)

1. R. Hay, Chemia bionieorganiczna, PWN 1990.

2. S. Lippard, J.M. Berg, Podstawy chemii bionieorganicznej, PWN 1998.

3. I. Bertini, H. B. Gray, S. J. Lippard, J.S. Valentine, Bioinorganic chemistry, University Science Books

4. G. Bartosz, Druga twarz tlenu, PWN 2003.

5. H. Koroniak, J. Barciszewski, Na pograniczu chemii i biologii, Wydawnictwo Naukowe UAM, Poznań 2000.

6. L. Stryer, Biochemia, PWN 2007.

7. J.M. Perez, M.A. Fuertes, C. Alonso, Metal Compound in Cancer Chemotherapy, Research Singpost, India 2005.

8. B. Lippert, Cisplatin. Chemistry and Biochemistry of a Leading Anticancer Drug, Wiley-VCH, Weinheim 1999.

9. G. M. Blackburn, M. J.Gait, D. Loakes, D.M. Williams, Nucleic Acids in Chemistry and Biology, RSC2006.

10. H-B. Kraatz, N. Metzler-Nolte, Concepts and models in Bioinorganic Chemistry, Wiley 2006.

Classes in period "Summer semester 2024/25" (in progress)

Time span: 2025-02-24 - 2025-09-20
Selected timetable range:
Go to timetable
Type of class:
Laboratory, 15 hours more information
Lecture, 15 hours more information
Coordinators: Iwona Łakomska
Group instructors: Adriana Kaszuba, Iwona Łakomska
Students list: (inaccessible to you)
Credit: Course - Examination
Laboratory - Grading
Lecture - Examination

Classes in period "Summer semester 2025/26" (future)

Time span: 2026-02-23 - 2026-09-20
Selected timetable range:
Go to timetable
Type of class:
Laboratory, 15 hours more information
Lecture, 15 hours more information
Coordinators: Iwona Łakomska
Group instructors: Iwona Łakomska
Students list: (inaccessible to you)
Credit: Course - Examination
Laboratory - Grading
Lecture - Examination
Course descriptions are protected by copyright.
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